Structure Elucidation of Olanzapine Molecular Salts by Combining Mechanochemistry and Micro-Electron Diffraction

Olanzapine (OLN), an antipsychotic drug, is one of the most widely studied pharmaceutical materials. Although OLN and their multicomponent solids are highly crystalline, some molecular salts difficult to crystallize optimization takes a long time. After several batches failed crystallization, we applied mechanochemistry microcrystal electron diffraction (MicroED) for structure elucidation. This combined approach was successful not only in determination drug molecule but also characterizing traces impurity present bulk solid. study demonstrates that fast efficient elucidation materials when generation suitable single crystals challenging.